Targeting Inflammatory Demyelinating Lesions to Sites of Wallerian Degeneration

Wallerian degeneration of the pontocerebellar fibers.

Two cases of pontine infarct with Wallerian degeneration (WD) of the pontocerebellar fibers are described. WD of pontocerebellar fibers, seen bilaterally along the transverse pontine fibers, is more visible in the middle cerebellar peduncles and extends into the white matter of the cerebellar hemispheres. Understanding the anatomy of the white matter and the temporal evolution of this degenerat...

Brain microbiota disruption within inflammatory demyelinating lesions in multiple sclerosis

Microbial communities reside in healthy tissues but are often disrupted during disease. Bacterial genomes and proteins are detected in brains from humans, nonhuman primates, rodents and other species in the absence of neurological disease. We investigated the composition and abundance of microbiota in frozen and fixed autopsied brain samples from patients with multiple sclerosis (MS) and age- a...

Inflammatory demyelinating brain lesions heralding primary CNS lymphoma.

Brain biopsy plays a crucial role in the exploration of suspect white matter lesions in the differential diagnosis of primary central nervous system lymphoma (PCNSL) and inflammatory demyelination. We present the case of a previously healthy, immunocompetent woman, aged fifty-nine, who developed a histologically confirmed demyelinating white matter lesion months prior to the manifestation of a ...

Is Hemorrhagic Demyelinating Lesions of Central Nervous System a Spectrum?

Wallerian Degeneration of the Superior Cerebellar Peduncle.

(1000mgat days0 and 14). She continued to experienceworseninglowerextremityweakness.Eventually,shereceived6plasmapheresis treatments withminimal improvement. During the entire periodof follow-up at our center, she required 20 to 30mg daily of oral prednisone. Neurological examination prior to the onset of HiCy therapy revealed symmetrically reduced arm abduction (4−/5) and hip flexion strength ...